A Mouse Model That Mimics AIDS-Related Cytomegalovirus Retinitis: Insights into Pathogenesis

Cytomegalovirus retinitis in AIDS.

Cytomegalovirus retinitis is common in adults with AIDS but has been reported infrequently in children with perinatally acquired HIV infection. The cases are presented of two infants with vertically acquired HIV infection who developed disseminated cytomegalovirus infection and retinitis, and who posed difficult management issues.

'Creeping' cytomegalovirus retinitis in AIDS.

Mortality in Patients With AIDS-Related Cytomegalovirus Retinitis in Myanmar

TO THE EDITOR—Retinitis is the most common clinical manifestation of human immunodeficiency virus (HIV)–related cytomegalovirus (CMV) disease, but there is irrefutable clinical [1] and autopsy [2] evidence that AIDS-related CMV retinitis is only part of a systemic infection. By virtue of this association with systemic disease, CMV retinitis both predicts and contributes to mortality [3], and sy...

Advances in the management of AIDS-related cytomegalovirus retinitis.

Cytomegalovirus (CMV) retinitis, a common complication of the acquired immunodeficiency syndrome (AIDS), is increasing in frequency as patients infected with the human immunodeficiency virus (HIV) live longer. In recent years, the lifetime risk for CMV disease in HIV-infected persons has increased from 24.9% to 44.9%. Cytomegalovirus retinitis is usually diagnosed clinically: Almost all patient...

The management of cytomegalovirus retinitis in AIDS.

Cytomegalovirus (CMV) shares many properties with other members of the herpesvirus family it exhibits latency, reactivates under suitable conditions to cause human disease, and it is incurable. CMV is the primary opportunistic viral infection in the immunosuppressed person and gives rise to a wide spectrum of disease. CMV is a major cause ofmorbidity and mortality among patients with AIDS, and ...